Monergism is an essential part of New England Theology that sees Christian salvation as a supernatural change of heart (regeneration) and the indwelling of the Holy Spirit.  These two doctrines were the cornerstone of "experiential" New Light Calvinist theology, emphasizing that saving faith and saving repentance could not be produced by human will power or mere religious ritual, but required an immediate, supernatural. sovereign act of God.

Four things in the Bible are monergistic:

1) Creation: God spoke the universe into existence out of nothing without human help (Hebrews 11:3).

2) Election:  God chose individuals before the foundation of the world according to His own sovereign will (Ephesians 1:4-5).

3) Resurrection: The transformation of saints' bodies from corruptible to incorruptible will be by God’s sovereign power alone (1 Corinthians 15:50).

4) Regeneration: The Scriptures that apply to the resurrection can be applied to regeneration.

1. Spiritual Resurrection (Regeneration) Scripture frequently describes salvation not merely as moral improvement, but as a literal resurrection from spiritual death. In Ephesians 2:1–5, the Apostle Paul states that believers who were "dead in trespasses and sins", God has made "alive together with Christ." A corpse cannot assist in its own resuscitation; likewise, a spiritually dead soul relies entirely on the unilateral, monergistic call of God to receive faith. Ezekiel 36:26: God promises, "I will give you a new heart... I will remove the heart of stone from your flesh and give you a heart of flesh." The recipient of the new heart is completely passive in the surgery.

2. Physical Resurrection: Just as the Holy Spirit enters a spiritually dead heart to grant faith, the Holy Spirit will quicken the saint's physically dead body. John 5:24–25: Jesus Christ unites these two concepts many times in a single sermon. He first speaks of spiritual regeneration: "he who hears My Word... has passed from death into life", and immediately follows it in verses 28–29 by speaking of physical resurrection: "All who are in the graves will hear His voice and come forth". He does it again in John 6:37-39: “All that the Father gives Me will come to Me…I should lose nothing, but should raise it up at the last day”. He does it again in John 6:44: “No one can come to Me unless the Father who sent Me draws him; and I will raise him up at the last day”.

The Apostle Paul unites the two concepts in Romans 8:11: "If the Spirit of Him who raised Jesus from the dead dwells in you, He who raised Christ Jesus from the dead will also give life to your mortal bodies through His Spirit who dwells in you". Regeneration is the down payment on resurrection. Paul does it again a little later in Romans 8:23: “We also who have the firstfruits of the Spirit, even we ourselves groan within ourselves, eagerly waiting for the adoption, the redemption of our body”. In Philippians 3:12-20, Paul says, “I press on, that I may lay hold of that for which Christ Jesus has also laid hold of me…who will transform our lowly body that it may be conformed to His glorious body”.

The Greek word palingenesia is used for the supernatural regeneration of sinners to saints in Titus 3:5: “According to His mercy He saved us, through the washing of regeneration and renewing of the Holy Spirit”, and the supernatural regeneration of the resurrection in Matthew 19:28: “in the regeneration, when the Son of Man sits on the throne of His glory”.

The exact same Holy Spirit who enters a person monergistically when they are supernaturally born again, will supernaturally raise the saint's bodies on the last day.|

Ephesians 2:5: “Even when we were dead in trespasses, (God) made us alive together with Christ (by grace you have been saved)”.

Ephesians 2:8: “by grace you have been saved through faith, and that not of yourselves; it is the gift of God”.

Romans 9:16: “So then it is not of him who wills, nor of him who runs, but of God who shows mercy”.

In Ezekiel 36:26-27, God speaks monergistically: "I will" statements: "I will give you a new heart... I will remove the heart of stone... I will put my Spirit within you, and cause you to walk in my statutes." The Old Testament prophesy was repeated in the New Testament description of regeneration in Hebrews 8:10-11: “I will put my laws into their mind, and write them in their hearts: and I will be to them a God, and they shall be to me a people: And they shall not teach every man his neighbor, and every man his brother, saying, Know the Lord: for all shall know me".

In Deuteronomy 30:6, the sinner is the recipient of the surgery, not a co-surgeon. "And the Lord your God will circumcise your heart" Like physical circumcision, the spiritual cutting away of the old nature is performed by another party. The Old Testament prophesy was repeated in the New Testament description of regeneration in Romans 2:29: "He is a Jew who is one inwardly; and circumcision is that of the heart, in the Spirit, not in the letter; whose praise is not from men but from God", and Colossians 2:11-13: "In Him you were also circumcised with the circumcision made without hands ... And you, being dead in your trespasses and the uncircumcision of your flesh, He has made alive together with Him".

John 1:12-13: “But as many as received Him, to them He gave the right to become children of God, to those who believe in His name: who were born, not of blood, nor of the will of the flesh, nor of the will of man, but of God”. This explicitly denies human volition as the source of the new birth. John 3:8: Jesus compares the Spirit’s work in regeneration to the wind: "The wind blows where it wishes... So it is with everyone who is born of the Spirit." The wind acts sovereignly, outside human command or cooperation. James 1:18: "Of his own will he brought us forth by the Word of truth". Rebirth originates strictly in the sovereign choice and will of God. Titus 3:5: God saved us "not because of works done by us in righteousness, but according to his own mercy, by the washing of regeneration and renewal of the Holy Spirit."

The Puritans rejected the idea of baptismal regeneration (that water baptism saves a person) and instead taught that human nature is entirely corrupted by sin. Because a person is spiritually "dead," salvation requires a supernatural, monergistic act of the Holy Spirit.

According to main doctrinal guide for Puritans, the Westminster Confession, The new creature in Christ (2 Corinthians 5:17), is made by regeneration by God’s powerful work of taking away a "heart of stone" and giving a "heart of flesh," spiritually transforming the human will so the saint can freely choose faith and repentance

For New England Puritans, the Holy Spirit was not just a theological concept, but an active, personal, immediate presence inside the believer. This idea has been entirely lost to the many denominations perverted by the Scottish Common Sense Realism "verbal restrictive" theory of the Holy Spirit.

Puritans believed in the mystical union of God and the saint (1 Corinthians 6:17). This takes place at supernatuiral regeneration, when the Holy Spirit inhabits the saint, and the saint becomes one spirit with God.

Jonathan Edwards and his disciples Bellamy, Hopkins and Emmons adapted New England salvation theology to include a distinction between the sinner's natural ability and moral inability to choose God over self. This provided New Light Calvinists the justication to not hesitate to call all sinners to repentance without the caveat that God hade to first regenerate them. The irony is no preacher in the Bible ever cited that caveat when telling sinners to repent.